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ENSA

CANCER ATLAS

Gene description

 Endosulfine alpha

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051294

GENE INFORMATION

Gene name

 ENSA (HGNC Symbol)

Synonyms

 ARPP-19e, MGC4319, MGC78563, MGC8394

Description

 Endosulfine alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 150600851 - 150629612

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143420 (version 83.38)

Entrez gene

 2029

UniProt

 O43768 (UniProt - Evidence at protein level)

neXtProt

 NX_O43768

Antibodypedia

 ENSA antibodies

PROTEIN BROWSER
«
ENSA-001
ENSA-002
ENSA-003
ENSA-004
ENSA-005
ENSA-006
ENSA-007
ENSA-008
ENSA-010
ENSA-012
ENSA-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENSA-001
ENSP00000358010
ENST00000369014
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 121 aa
13.4 kDa 		No 0
ENSA-002
ENSP00000271690
ENST00000271690
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 117 aa
13 kDa 		No 0
ENSA-003
ENSP00000355220
ENST00000362052
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 105 aa
12 kDa 		No 0
ENSA-004
ENSP00000358012
ENST00000369016
Q5T5H1 [Direct mapping]
Alpha-endosulfine
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 187 aa
21 kDa 		No 0
ENSA-005
ENSP00000355239
ENST00000361631
O43768 [Direct mapping]
Alpha-endosulfine
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 133 aa
14.7 kDa 		No 0
ENSA-006
ENSP00000341743
ENST00000339643
O43768 [Direct mapping]
Alpha-endosulfine
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009749 [response to glucose]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 137 aa
15.3 kDa 		No 0
ENSA-007
ENSP00000422343
ENST00000513281
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 113 aa
12.4 kDa 		No 0
ENSA-008
ENSP00000354835
ENST00000361532
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 117 aa
12.8 kDa 		No 0
ENSA-010
ENSP00000348921
ENST00000356527
A6NMQ3 [Direct mapping]
Alpha-endosulfine
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
15.6 kDa 		No 0
ENSA-012
ENSP00000421458
ENST00000503345
O43768 [Direct mapping]
Alpha-endosulfine
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 105 aa
12 kDa 		No 0
ENSA-015
ENSP00000424242
ENST00000503241
O43768 [Direct mapping]
Alpha-endosulfine
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0007067 [mitotic nuclear division]
GO:0007584 [response to nutrient]
GO:0008200 [ion channel inhibitor activity]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0019212 [phosphatase inhibitor activity]
GO:0019870 [potassium channel inhibitor activity]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0050796 [regulation of insulin secretion]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 133 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.