Tissue expression of SEMA6C - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEMA6C
Gene description	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SEMA6C (HGNC Symbol)
Synonyms	KIAA1869
Description	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	151131685 - 151146664
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143434 (version 83.38)
Entrez gene	10500
UniProt	Q9H3T2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H3T2
Antibodypedia	SEMA6C antibodies

PROTEIN BROWSER

SEMA6C-001	SEMA6C-002	SEMA6C-003	SEMA6C-004	SEMA6C-201	SEMA6C-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEMA6C-001 ENSP00000357910 ENST00000368914	Q9H3T2 [Direct mapping] Semaphorin-6C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	930 aa 99.7 kDa	Yes	1
SEMA6C-002 ENSP00000357909 ENST00000368913	Q9H3T2 [Direct mapping] Semaphorin-6C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	962 aa 102.9 kDa	Yes	1
SEMA6C-003 ENSP00000357908 ENST00000368912	Q9H3T2 [Direct mapping] Semaphorin-6C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	922 aa 98.5 kDa	Yes	1
SEMA6C-004 ENSP00000344148 ENST00000341697	Q9H3T2 [Direct mapping] Semaphorin-6C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	930 aa 99.7 kDa	Yes	1
SEMA6C-201 ENSP00000482163 ENST00000613223	A0A087WYX3 [Direct mapping] Semaphorin-6C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	537 aa 59.3 kDa	Yes	0
SEMA6C-202 ENSP00000483227 ENST00000621728	A0A087X0A5 [Direct mapping] Semaphorin-6C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	537 aa 59.3 kDa	Yes	0