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One case of glioma showed moderate cytoplasmic immunoreactivity. A single case of colorectal cancer exhibited strong nucleolar positivity. Moderate nucleolar positivity was observed in a single case of seminoma. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
KCNH1 (HGNC Symbol)
Synonyms
eag, eag1, h-eag, Kv10.1
Description
Potassium channel, voltage gated eag related subfamily H, member 1 (HGNC Symbol)
Entrez gene summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]