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Most skin cancers and a few cases of cervical squamous cell carcinomas exhibited strong cytoplasmic immunoreactivity. The remaining malignant tissues were in general negative.
Occasional cases of basal cell carcinomas and cervical cancer displayed strong staining. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
CRNN (HGNC Symbol)
Synonyms
C1orf10, SEP53
Description
Cornulin (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ""fused gene"" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
