Tissue expression of TPM3 - Summary - The Human Protein Atlas

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TPM3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TPM3
Gene description	Tropomyosin 3
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)
FANTOM5:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression, mainly in skeletal myocytes.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 4 antibodies. HPA000261 , HPA009066 , HPA047089 , HPA053624
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	TPM3 (HGNC Symbol)
Synonyms	NEM1, TRK
Description	Tropomyosin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	154155304 - 154194648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143549 (version 83.38)
Entrez gene	7170
UniProt	P06753 (UniProt - Evidence at protein level)
neXtProt	NX_P06753
Antibodypedia	TPM3 antibodies

PROTEIN BROWSER

TPM3-001	TPM3-003	TPM3-004	TPM3-005	TPM3-006	TPM3-009	TPM3-010	TPM3-011	TPM3-015	TPM3-018	TPM3-026	TPM3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPM3-001 ENSP00000357516 ENST00000368530	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0002102 [podosome] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0030049 [muscle filament sliding] GO:0030426 [growth cone] GO:0030863 [cortical cytoskeleton] GO:0031941 [filamentous actin] GO:0032154 [cleavage furrow] GO:0043005 [neuron projection] GO:0070062 [extracellular exosome] Show all	285 aa 32.9 kDa	No	0
TPM3-003 ENSP00000341653 ENST00000341485	Q5HYB6 [Direct mapping] Epididymis luminal protein 189; Putative uncharacterized protein DKFZp686J1372; Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		232 aa 27.2 kDa	No	0
TPM3-004 ENSP00000357521 ENST00000368533	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	248 aa 29 kDa	No	0
TPM3-005 ENSP00000339378 ENST00000341372	Q5VU61 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		223 aa 26.1 kDa	No	0
TPM3-006 ENSP00000357520 ENST00000328159	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	248 aa 28.9 kDa	No	0
TPM3-009 ENSP00000339035 ENST00000330188	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	248 aa 28.9 kDa	No	0
TPM3-010 ENSP00000357518 ENST00000323144	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	247 aa 28.8 kDa	No	0
TPM3-011 ENSP00000307712 ENST00000302206	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0007155 [cell adhesion] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	158 aa 18.6 kDa	No	0
TPM3-015 ENSP00000271850 ENST00000271850	J3KN67 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		285 aa 33.2 kDa	No	0
TPM3-018 ENSP00000426306 ENST00000515609	D6RGJ6 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.7 kDa	No	0
TPM3-026 ENSP00000357517 ENST00000368531	P06753 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005862 [muscle thin filament tropomyosin] GO:0006928 [movement of cell or subcellular component] GO:0006936 [muscle contraction] GO:0030049 [muscle filament sliding] GO:0070062 [extracellular exosome] Show all	247 aa 29 kDa	No	0
TPM3-201 ENSP00000480520 ENST00000611659	A0A087WWU8 [Direct mapping] Tropomyosin alpha-3 chain Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		227 aa 26.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.