Cell atlas - CREB3L4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CREB3L4

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nuclear membrane
	Nucleoplasm

Human cell
	Mitochondria
	Nuclear membrane
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CREB3L4
Gene description	CAMP responsive element binding protein 3-like 4
Protein class	Predicted intracellular proteins Predicted membrane proteins Transcription factors
Predicted localization	Intracellular,Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear membrane (approved)
Additional location	In addition localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038122
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the mitochondria.

Main location

Nucleoplasm (approved), Nuclear membrane (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038122	A-431	Nucleoplasm
			Nuclear membrane
			Mitochondria	Intensity
	HPA038122	U-2 OS	Nucleoplasm
			Nuclear membrane
			Mitochondria	Intensity
	HPA038122	U-251 MG	Nucleoplasm
	HPA038122	U-251 MG	Nuclear membrane

GENE INFORMATION
Gene name	CREB3L4 (HGNC Symbol)
Synonyms	AIbZIP, ATCE1, CREB3, CREB4, hJAL
Description	CAMP responsive element binding protein 3-like 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	153967534 - 153974363
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143578 (version 83.38)
Entrez gene	148327
UniProt	Q8TEY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TEY5
Antibodypedia	CREB3L4 antibodies

PROTEIN BROWSER

CREB3L4-001	CREB3L4-002	CREB3L4-003	CREB3L4-004	CREB3L4-006	CREB3L4-007	CREB3L4-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CREB3L4-001 ENSP00000271889 ENST00000271889	Q8TEY5 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	395 aa 43.4 kDa	No	1
CREB3L4-002 ENSP00000357596 ENST00000368607	Q8TEY5 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	395 aa 43.4 kDa	No	1
CREB3L4-003 ENSP00000357592 ENST00000368603	Q8TEY5 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	395 aa 43.4 kDa	No	1
CREB3L4-004 ENSP00000357589 ENST00000368600	Q8TEY5 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Basic domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006355 [regulation of transcription, DNA-templated] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	375 aa 41.3 kDa	No	1
CREB3L4-006 ENSP00000391847 ENST00000449724	Q5T4L1 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	228 aa 25.1 kDa	No	0
CREB3L4-007 ENSP00000402308 ENST00000431292	Q5T4L2 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	182 aa 19.5 kDa	No	0
CREB3L4-012 ENSP00000357590 ENST00000368601	Q5T4K9 [Direct mapping] Cyclic AMP-responsive element-binding protein 3-like protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0035497 [cAMP response element binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	217 aa 23.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.