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Most malignancies were moderately positive. Testis, thyroid, liver, gastric cancers displayed strong staining in several cases. Lymphoma, lung, ovarian and cervical cancers were weakly stained in many cases.
GENE INFORMATION
Gene name
EFNA3 (HGNC Symbol)
Synonyms
Ehk1-L, EPLG3, LERK3
Description
Ephrin-A3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]