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GALNT2

GENERAL INFORMATION

Gene name

 GALNT2

Gene description

 Polypeptide N-acetylgalactosaminyltransferase 2

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA011222
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GALNT2 (HGNC Symbol)

Synonyms

 GalNAc-T2

Description

 Polypeptide N-acetylgalactosaminyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 230057990 - 230282124

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143641 (version 83.38)

Entrez gene

 2590

UniProt

 Q10471 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10471

Antibodypedia

 GALNT2 antibodies

PROTEIN BROWSER
GALNT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GALNT2-001
ENSP00000355632
ENST00000366672
Q10471 [Direct mapping]
Polypeptide N-acetylgalactosaminyltransferase 2 Polypeptide N-acetylgalactosaminyltransferase 2 soluble form
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002378 [immunoglobulin biosynthetic process]
GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016266 [O-glycan processing]
GO:0018242 [protein O-linked glycosylation via serine]
GO:0018243 [protein O-linked glycosylation via threonine]
GO:0030145 [manganese ion binding]
GO:0030173 [integral component of Golgi membrane]
GO:0030246 [carbohydrate binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 571 aa
64.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.