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ARF1

CANCER ATLAS

Gene description

 ADP-ribosylation factor 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB007742

GENE INFORMATION

Gene name

 ARF1

Synonyms

Description

 ADP-ribosylation factor 1 (HGNC Symbol)

Entrez gene summary

 ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 228082660 - 228099212

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143761 (version 83.38)

Entrez gene

 375

UniProt

 P84077 (UniProt - Evidence at protein level)

neXtProt

 NX_P84077

Antibodypedia

 ARF1 antibodies

PROTEIN BROWSER
ARF1-001
ARF1-201
ARF1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARF1-001
ENSP00000272102
ENST00000272102
P84077 [Direct mapping]
ADP-ribosylation factor 1
A0A024R3Q3 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002090 [regulation of receptor internalization]
GO:0003924 [GTPase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006878 [cellular copper ion homeostasis]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031252 [cell leading edge]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050690 [regulation of defense response to virus by virus]
GO:0060292 [long term synaptic depression]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097061 [dendritic spine organization]
Show all
 181 aa
20.7 kDa 		No 0
ARF1-201
ENSP00000442980
ENST00000540651
P84077 [Direct mapping]
ADP-ribosylation factor 1
A0A024R3Q3 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002090 [regulation of receptor internalization]
GO:0003924 [GTPase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006878 [cellular copper ion homeostasis]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0031252 [cell leading edge]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050690 [regulation of defense response to virus by virus]
GO:0060292 [long term synaptic depression]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097061 [dendritic spine organization]
Show all
 181 aa
20.7 kDa 		No 0
ARF1-202
ENSP00000440005
ENST00000541182
P84077 [Direct mapping]
ADP-ribosylation factor 1
A0A024R3Q3 [Target identity:100%; Query identity:100%]
ADP-ribosylation factor 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000287 [magnesium ion binding]
GO:0002090 [regulation of receptor internalization]
GO:0003924 [GTPase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005770 [late endosome]
GO:0005778 [peroxisomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006878 [cellular copper ion homeostasis]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007015 [actin filament organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0012505 [endomembrane system]
GO:0014069 [postsynaptic density]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019003 [GDP binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030017 [sarcomere]
GO:0030137 [COPI-coated vesicle]
GO:0031252 [cell leading edge]
GO:0034315 [regulation of Arp2/3 complex-mediated actin nucleation]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0043005 [neuron projection]
GO:0043085 [positive regulation of catalytic activity]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045211 [postsynaptic membrane]
GO:0045807 [positive regulation of endocytosis]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050714 [positive regulation of protein secretion]
GO:0055108 [Golgi to transport vesicle transport]
GO:0060292 [long term synaptic depression]
GO:0060999 [positive regulation of dendritic spine development]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070142 [synaptic vesicle budding]
GO:0097061 [dendritic spine organization]
GO:0097212 [lysosomal membrane organization]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902824 [positive regulation of late endosome to lysosome transport]
GO:1902953 [positive regulation of ER to Golgi vesicle-mediated transport]
GO:1903725 [regulation of phospholipid metabolic process]
GO:1990583 [phospholipase D activator activity]
Show all
 181 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.