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The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
P27987 [Direct mapping] Inositol-trisphosphate 3-kinase B
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0001932 [regulation of protein phosphorylation] GO:0002262 [myeloid cell homeostasis] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0008440 [inositol-1,4,5-trisphosphate 3-kinase activity] GO:0016020 [membrane] GO:0030217 [T cell differentiation] GO:0033030 [negative regulation of neutrophil apoptotic process] GO:0035726 [common myeloid progenitor cell proliferation] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0045059 [positive thymic T cell selection] GO:0045061 [thymic T cell selection] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0046638 [positive regulation of alpha-beta T cell differentiation]
