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REN

CANCER ATLAS

Gene description

 Renin

Protein class

 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005131
CAB025903

GENE INFORMATION

Gene name

 REN

Synonyms

Description

 Renin (HGNC Symbol)

Entrez gene summary

 Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 204154819 - 204166322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143839 (version 83.38)

Entrez gene

 5972

UniProt

 P00797 (UniProt - Evidence at protein level)

neXtProt

 NX_P00797

Antibodypedia

 REN antibodies

PROTEIN BROWSER
REN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
REN-001
ENSP00000272190
ENST00000272190
P00797 [Direct mapping]
Renin
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0002003 [angiotensin maturation]
GO:0002016 [regulation of blood volume by renin-angiotensin]
GO:0002018 [renin-angiotensin regulation of aldosterone production]
GO:0004175 [endopeptidase activity]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008233 [peptidase activity]
GO:0008584 [male gonad development]
GO:0009755 [hormone-mediated signaling pathway]
GO:0010033 [response to organic substance]
GO:0032496 [response to lipopolysaccharide]
GO:0035690 [cellular response to drug]
GO:0035902 [response to immobilization stress]
GO:0042493 [response to drug]
GO:0042756 [drinking behavior]
GO:0043408 [regulation of MAPK cascade]
GO:0044267 [cellular protein metabolic process]
GO:0048469 [cell maturation]
GO:0050435 [beta-amyloid metabolic process]
GO:0051591 [response to cAMP]
GO:0070305 [response to cGMP]
Show all
 406 aa
45.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.