Expression of PLEKHA6 in cancer - Summary

CANCER ATLAS

Gene description

Pleckstrin homology domain containing, family A member 6

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA028152

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Moderate to strong cytoplasmic and membranous immunoreactivity was observed in colorectal cancers. A majority of pancreatic cancers and a few testicular cancers were moderately stained. Remaining cancer cells were in general negative.

GENE INFORMATION
Gene name	PLEKHA6 (HGNC Symbol)
Synonyms	KIAA0969, PEPP3
Description	Pleckstrin homology domain containing, family A member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	204218851 - 204377665
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143850 (version 83.38)
Entrez gene	22874
UniProt	Q9Y2H5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2H5
Antibodypedia	PLEKHA6 antibodies

PROTEIN BROWSER

PLEKHA6-001	PLEKHA6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA6-001 ENSP00000272203 ENST00000272203	Q9Y2H5 [Direct mapping] Pleckstrin homology domain-containing family A member 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		1048 aa 117.1 kDa	No	0
PLEKHA6-002 ENSP00000402046 ENST00000414478	Q5VTI5 [Direct mapping] Pleckstrin homology domain-containing family A member 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1068 aa 119.3 kDa	No	0