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GDF7

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GENERAL INFORMATION

Gene name

 GDF7

Gene description

 Growth differentiation factor 7

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (RT4, SH-SY5Y, Hep G2)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, SH-SY5Y, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GDF7 (HGNC Symbol)

Synonyms

 BMP12

Description

 Growth differentiation factor 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p24.1

Chromosome location (bp)

 20666664 - 20679245

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000143869 (version 83.38)

Entrez gene

 151449

UniProt

 Q7Z4P5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q7Z4P5

Antibodypedia

 GDF7 antibodies

PROTEIN BROWSER
GDF7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDF7-001
ENSP00000272224
ENST00000272224
Q7Z4P5 [Direct mapping]
Growth/differentiation factor 7
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0010628 [positive regulation of gene expression]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0021509 [roof plate formation]
GO:0021527 [spinal cord association neuron differentiation]
GO:0021915 [neural tube development]
GO:0022612 [gland morphogenesis]
GO:0030509 [BMP signaling pathway]
GO:0030855 [epithelial cell differentiation]
GO:0030901 [midbrain development]
GO:0032924 [activin receptor signaling pathway]
GO:0040007 [growth]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045165 [cell fate commitment]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048468 [cell development]
GO:0048608 [reproductive structure development]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048853 [forebrain morphogenesis]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060571 [morphogenesis of an epithelial fold]
GO:2001051 [positive regulation of tendon cell differentiation]
Show all
 450 aa
47 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.