Cell atlas - ATP6V1C2 - The Human Protein Atlas

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ATP6V1C2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	ATP6V1C2
Gene description	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Group enriched (BEWO, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA034734
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BEWO, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034734	A-431	Mitochondria
	HPA034734	U-2 OS	Mitochondria
	HPA034734	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	ATP6V1C2 (HGNC Symbol)
Synonyms	ATP6C2, VMA5
Description	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10721649 - 10785110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143882 (version 83.38)
Entrez gene	245973
UniProt	Q8NEY4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEY4
Antibodypedia	ATP6V1C2 antibodies

PROTEIN BROWSER

ATP6V1C2-001	ATP6V1C2-002	ATP6V1C2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V1C2-001 ENSP00000371077 ENST00000381661	Q8NEY4 [Direct mapping] V-type proton ATPase subunit C 2 Show all	Transporters Primary Active Transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005829 [cytosol] GO:0006879 [cellular iron ion homeostasis] GO:0008286 [insulin receptor signaling pathway] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046983 [protein dimerization activity] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0090382 [phagosome maturation] Show all	381 aa 43.9 kDa	No	0
ATP6V1C2-002 ENSP00000272238 ENST00000272238	Q8NEY4 [Direct mapping] V-type proton ATPase subunit C 2 Show all	Transporters Primary Active Transporters MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005829 [cytosol] GO:0006879 [cellular iron ion homeostasis] GO:0008286 [insulin receptor signaling pathway] GO:0008553 [hydrogen-exporting ATPase activity, phosphorylative mechanism] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046983 [protein dimerization activity] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0090382 [phagosome maturation] Show all	427 aa 48.8 kDa	No	0
ATP6V1C2-005 ENSP00000489280 ENST00000635370		MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0033180 [proton-transporting V-type ATPase, V1 domain] Show all	437 aa 49.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.