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WDPCP

CANCER ATLAS

Gene description

 WD repeat containing planar cell polarity effector

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044144

GENE INFORMATION

Gene name

 WDPCP (HGNC Symbol)

Synonyms

 BBS15, C2orf86, fritz, hFrtz

Description

 WD repeat containing planar cell polarity effector (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 63121383 - 63827843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143951 (version 83.38)

Entrez gene

 51057

UniProt

 O95876 (UniProt - Evidence at protein level)

neXtProt

 NX_O95876

Antibodypedia

 WDPCP antibodies

PROTEIN BROWSER
WDPCP-001
WDPCP-002
WDPCP-005
WDPCP-007
WDPCP-008
WDPCP-011
WDPCP-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDPCP-001
ENSP00000386769
ENST00000409120
E9PFG9 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 554 aa
62.9 kDa 		No 0
WDPCP-002
ENSP00000272321
ENST00000272321
O95876 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002093 [auditory receptor cell morphogenesis]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005930 [axoneme]
GO:0005938 [cell cortex]
GO:0007224 [smoothened signaling pathway]
GO:0007399 [nervous system development]
GO:0010762 [regulation of fibroblast migration]
GO:0016324 [apical plasma membrane]
GO:0016476 [regulation of embryonic cell shape]
GO:0032185 [septin cytoskeleton organization]
GO:0032880 [regulation of protein localization]
GO:0042384 [cilium assembly]
GO:0042733 [embryonic digit morphogenesis]
GO:0043010 [camera-type eye development]
GO:0044782 [cilium organization]
GO:0045184 [establishment of protein localization]
GO:0048568 [embryonic organ development]
GO:0051893 [regulation of focal adhesion assembly]
GO:0055123 [digestive system development]
GO:0060021 [palate development]
GO:0060271 [cilium morphogenesis]
GO:0060541 [respiratory system development]
GO:0072358 [cardiovascular system development]
GO:0090521 [glomerular visceral epithelial cell migration]
GO:0097541 [axonemal basal plate]
GO:1900027 [regulation of ruffle assembly]
GO:2000114 [regulation of establishment of cell polarity]
Show all
 746 aa
85.1 kDa 		No 0
WDPCP-005
ENSP00000387222
ENST00000409562
O95876 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005930 [axoneme]
GO:0005938 [cell cortex]
GO:0016324 [apical plasma membrane]
GO:0016476 [regulation of embryonic cell shape]
GO:0032185 [septin cytoskeleton organization]
GO:0032880 [regulation of protein localization]
GO:0060271 [cilium morphogenesis]
Show all
 618 aa
71 kDa 		No 0
WDPCP-007
ENSP00000381552
ENST00000398544
O95876 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005930 [axoneme]
GO:0005938 [cell cortex]
GO:0016324 [apical plasma membrane]
GO:0016476 [regulation of embryonic cell shape]
GO:0032185 [septin cytoskeleton organization]
GO:0032880 [regulation of protein localization]
GO:0060271 [cilium morphogenesis]
Show all
 587 aa
66.7 kDa 		No 0
WDPCP-008
ENSP00000386592
ENST00000409199
E9PFG9 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
Show all
 554 aa
62.9 kDa 		No 0
WDPCP-011
ENSP00000396226
ENST00000431065
C9JDS5 [Direct mapping]
WD repeat-containing and planar cell polarity effector protein fritz homolog
Show all
Predicted intracellular proteins
Show all
 85 aa
10.2 kDa 		No 0
WDPCP-013
ENSP00000430288
ENST00000473678
Predicted intracellular proteins
Show all
 8 aa
0.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.