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Several cases of squamous cell carcinomas of cervix and few cases of endometrial cancers showed weak to moderate nuclear staining. Several cases of ovarian cancers showed moderate positivity. Remaining cancer tissues were weakly stained or negative.
Weak to moderate cytoplasmic immunoreactivity was observed in the majority of cancer tissues. Most gliomas and skin cancers were negative. Occasional nuclear positivity was observed, especially in lymphomas, ovarian and cervical cancers.
GENE INFORMATION
Gene name
MEIS1
Synonyms
Description
Meis homeobox 1 (HGNC Symbol)
Entrez gene summary
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001525 [angiogenesis] GO:0002089 [lens morphogenesis in camera-type eye] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007626 [locomotory behavior] GO:0030097 [hemopoiesis] GO:0035855 [megakaryocyte development] GO:0043565 [sequence-specific DNA binding] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048514 [blood vessel morphogenesis] GO:0060216 [definitive hemopoiesis]
