Expression of SNRNP200 in cancer - Summary

CANCER ATLAS

Gene description

Small nuclear ribonucleoprotein 200kDa (U5)

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029321

GENE INFORMATION
Gene name	SNRNP200 (HGNC Symbol)
Synonyms	ASCC3L1, BRR2, HELIC2, KIAA0788, RP33, U5-200KD
Description	Small nuclear ribonucleoprotein 200kDa (U5) (HGNC Symbol)
Entrez gene summary	Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	96274336 - 96305515
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144028 (version 83.38)
Entrez gene	23020
UniProt	O75643 (UniProt - Evidence at protein level)
neXtProt	NX_O75643
Antibodypedia	SNRNP200 antibodies

PROTEIN BROWSER

SNRNP200-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNRNP200-001 ENSP00000317123 ENST00000323853	O75643 [Direct mapping] U5 small nuclear ribonucleoprotein 200 kDa helicase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000354 [cis assembly of pre-catalytic spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0001649 [osteoblast differentiation] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005682 [U5 snRNP] GO:0008026 [ATP-dependent helicase activity] GO:0008380 [RNA splicing] GO:0008565 [protein transporter activity] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0031204 [posttranslational protein targeting to membrane, translocation] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	2136 aa 244.5 kDa	No	0