Expression of SLC20A1 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 20 (phosphate transporter), member 1

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA035834	CAB019279

GENE INFORMATION
Gene name	SLC20A1 (HGNC Symbol)
Synonyms	Glvr-1, GLVR1, PiT-1
Description	Solute carrier family 20 (phosphate transporter), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	112645857 - 112663827
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144136 (version 83.38)
Entrez gene	6574
UniProt	Q8WUM9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUM9
Antibodypedia	SLC20A1 antibodies

PROTEIN BROWSER

SLC20A1-001	SLC20A1-005	SLC20A1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC20A1-001 ENSP00000272542 ENST00000272542	Q8WUM9 [Direct mapping] Sodium-dependent phosphate transporter 1 A7LNJ1 [Target identity:100%; Query identity:100%] Solute carrier family 20 (Phosphate transporter), member 1; Solute carrier family 20 (Phosphate transporter), member 1, isoform CRA_a; cDNA, FLJ93144, highly similar to Homo sapiens solute carrier family 20 (phosphate transporter), member 1 (SLC20A1), mRNA Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0004872 [receptor activity] GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0005316 [high-affinity inorganic phosphate:sodium symporter activity] GO:0005436 [sodium:phosphate symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006796 [phosphate-containing compound metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006817 [phosphate ion transport] GO:0007165 [signal transduction] GO:0015319 [sodium:inorganic phosphate symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035435 [phosphate ion transmembrane transport] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0055085 [transmembrane transport] Show all	679 aa 73.7 kDa	No	>9
SLC20A1-005 ENSP00000392050 ENST00000423633	H7BZY1 [Direct mapping] Sodium-dependent phosphate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	89 aa 10 kDa	No	2
SLC20A1-008 ENSP00000390021 ENST00000433924	H7BZK4 [Direct mapping] Sodium-dependent phosphate transporter 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005315 [inorganic phosphate transmembrane transporter activity] GO:0006817 [phosphate ion transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	213 aa 23.5 kDa	No	2