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POLR2D

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GENERAL INFORMATION

Gene name

 POLR2D

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide D

Protein class

 Plasma proteins
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nuclear speckles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA034694
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles & nucleoplasm.

Main location

 Nucleoplasm (supported), Nuclear speckles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA034694 HEK 293 Nuclear speckles
Cytosol
HPA034694 Hep G2 Nuclear speckles
HPA034694 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 POLR2D (HGNC Symbol)

Synonyms

 RBP4

Description

 Polymerase (RNA) II (DNA directed) polypeptide D (HGNC Symbol)

Entrez gene summary

 This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 127843551 - 127858157

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144231 (version 83.38)

Entrez gene

 5433

UniProt

 O15514 (UniProt - Evidence at protein level)

neXtProt

 NX_O15514

Antibodypedia

 POLR2D antibodies

PROTEIN BROWSER
POLR2D-001
POLR2D-002
POLR2D-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2D-001
ENSP00000272645
ENST00000272645
O15514 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB4
A0A024RAJ4 [Target identity:100%; Query identity:100%]
Polymerase (RNA) II (DNA directed) polypeptide D, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003697 [single-stranded DNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031369 [translation initiation factor binding]
GO:0031990 [mRNA export from nucleus in response to heat stress]
GO:0034402 [recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0044237 [cellular metabolic process]
GO:0045948 [positive regulation of translational initiation]
GO:0050434 [positive regulation of viral transcription]
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 142 aa
16.3 kDa 		No 0
POLR2D-002
ENSP00000387323
ENST00000409955
E9PHV4 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB4
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003697 [single-stranded DNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0031369 [translation initiation factor binding]
GO:0031990 [mRNA export from nucleus in response to heat stress]
GO:0034402 [recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex]
GO:0044237 [cellular metabolic process]
GO:0045948 [positive regulation of translational initiation]
Show all
 110 aa
12.8 kDa 		No 0
POLR2D-003
ENSP00000387117
ENST00000409698
E9PB93 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB4
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003697 [single-stranded DNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0031369 [translation initiation factor binding]
GO:0031990 [mRNA export from nucleus in response to heat stress]
GO:0034402 [recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex]
GO:0044237 [cellular metabolic process]
GO:0045948 [positive regulation of translational initiation]
Show all
 104 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.