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SLC4A10

GENERAL INFORMATION

Gene name

 SLC4A10

Gene description

 Solute carrier family 4, sodium bicarbonate transporter, member 10

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, cerebellum, hypothalamus, hippocampus, caudate)
FANTOM5:Group enriched (hippocampus, brain, caudate, cerebellum, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA034755
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, cerebellum, hypothalamus, hippocampus, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, brain, caudate, cerebellum, pituitary gland)

GENE INFORMATION

Gene name

 SLC4A10 (HGNC Symbol)

Synonyms

 NBCn2, NCBE

Description

 Solute carrier family 4, sodium bicarbonate transporter, member 10 (HGNC Symbol)

Entrez gene summary

 This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Chromosome

 2

Cytoband

 q24.2

Chromosome location (bp)

 161424332 - 161985282

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144290 (version 83.38)

Entrez gene

 57282

UniProt

 Q6U841 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6U841

Antibodypedia

 SLC4A10 antibodies

PROTEIN BROWSER
SLC4A10-001
SLC4A10-004
SLC4A10-009
SLC4A10-010
SLC4A10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A10-001
ENSP00000395797
ENST00000415876
Q6U841 [Direct mapping]
Sodium-driven chloride bicarbonate exchanger
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0006821 [chloride transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1088 aa
122.6 kDa 		No >9
SLC4A10-004
ENSP00000393066
ENST00000446997
Q6U841 [Direct mapping]
Sodium-driven chloride bicarbonate exchanger
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0006821 [chloride transport]
GO:0006885 [regulation of pH]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0009416 [response to light stimulus]
GO:0009791 [post-embryonic development]
GO:0015301 [anion:anion antiporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0021860 [pyramidal neuron development]
GO:0030641 [regulation of cellular pH]
GO:0035264 [multicellular organism growth]
GO:0035641 [locomotory exploration behavior]
GO:0035725 [sodium ion transmembrane transport]
GO:0043025 [neuronal cell body]
GO:0048854 [brain morphogenesis]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0097440 [apical dendrite]
GO:0097441 [basilar dendrite]
GO:0097442 [CA3 pyramidal cell dendrite]
GO:0098656 [anion transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 1118 aa
125.9 kDa 		No >9
SLC4A10-009
ENSP00000272716
ENST00000272716
C9J240 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 1106 aa
124.7 kDa 		No >9
SLC4A10-010
ENSP00000404486
ENST00000421911
E7EW28 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0098656 [anion transmembrane transport]
Show all
 1054 aa
118.8 kDa 		No >9
SLC4A10-201
ENSP00000364664
ENST00000375514
Q6U841 [Direct mapping]
Sodium-driven chloride bicarbonate exchanger
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0006821 [chloride transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1099 aa
123.8 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.