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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PHOSPHO2
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Phosphatase, orphan 2

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA034726
HPA034727

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer tissues showed moderate cytoplasmic staining with a granular pattern. Colorectal cancers along with occasional cases of melanomas and seminomas of testis showed strong immunoreactivity. Renal cancers and most cases of gliomas and lymphomas were weakly stained or negative.

Tissue

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Tissue

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in some cases. Lymphomas and cervical cancers were negative.

GENE INFORMATION

Gene name

PHOSPHO2 (HGNC Symbol)

Synonyms

MGC22679

Description

Phosphatase, orphan 2 (HGNC Symbol)

Entrez gene summary

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

169694454 - 169701708

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144362 (version 83.38)

Entrez gene

493911

UniProt

Q8TCD6 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TCD6

Antibodypedia

PHOSPHO2 antibodies

PROTEIN BROWSER

PHOSPHO2-001
PHOSPHO2-002
PHOSPHO2-003
PHOSPHO2-005
PHOSPHO2-201
PHOSPHO2-202
PHOSPHO2-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHOSPHO2-001
ENSP00000352782
ENST00000359744
Q8TCD6 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0033883 [pyridoxal phosphatase activity]
GO:0046872 [metal ion binding]
Show all
241 aa
27.8 kDa
No 0
PHOSPHO2-002
ENSP00000411844
ENST00000438710
C9J4G2 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
136 aa
15.8 kDa
No 0
PHOSPHO2-003
ENSP00000416790
ENST00000449906
C9JD35 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
49 aa
5.8 kDa
No 0
PHOSPHO2-005
ENSP00000393983
ENST00000438838
C9JZQ7 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Predicted intracellular proteins
Show all
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
56 aa
6.7 kDa
No 0
PHOSPHO2-201
ENSP00000481680
ENST00000616481
Q8TCD6 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0033883 [pyridoxal phosphatase activity]
GO:0046872 [metal ion binding]
Show all
241 aa
27.8 kDa
No 0
PHOSPHO2-202
ENSP00000481046
ENST00000616524
Q8TCD6 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0033883 [pyridoxal phosphatase activity]
GO:0046872 [metal ion binding]
Show all
241 aa
27.8 kDa
No 0
PHOSPHO2-203
ENSP00000481857
ENST00000617738
Q8TCD6 [Direct mapping]
Pyridoxal phosphate phosphatase PHOSPHO2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0033883 [pyridoxal phosphatase activity]
GO:0046872 [metal ion binding]
Show all
241 aa
27.8 kDa
No 0

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The Human Protein Atlas project is funded
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