Tissue expression of HES6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HES6
Gene description	Hes family bHLH transcription factor 6
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (pituitary gland)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION
Gene name	HES6 (HGNC Symbol)
Synonyms	bHLHb41
Description	Hes family bHLH transcription factor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	238238267 - 238240662
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000144485 (version 83.38)
Entrez gene	55502
UniProt	Q96HZ4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96HZ4
Antibodypedia	HES6 antibodies

PROTEIN BROWSER

HES6-001	HES6-002	HES6-003	HES6-004	HES6-005	HES6-006	HES6-007	HES6-008	HES6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HES6-001 ENSP00000272937 ENST00000272937	Q96HZ4 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0030154 [cell differentiation] GO:0046983 [protein dimerization activity] Show all	224 aa 24.1 kDa	No	0
HES6-002 ENSP00000387155 ENST00000409002	Q96HZ4 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0046983 [protein dimerization activity] Show all	222 aa 23.9 kDa	No	0
HES6-003 ENSP00000387215 ENST00000409160	Q96HZ4 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0046983 [protein dimerization activity] Show all	214 aa 23.5 kDa	No	0
HES6-004 ENSP00000392596 ENST00000436051	H7C020 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Show all		171 aa 17 kDa	No	0
HES6-005 ENSP00000387008 ENST00000409574	Q96HZ4 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Transcription factors Basic domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0046983 [protein dimerization activity] Show all	112 aa 12.2 kDa	No	0
HES6-006 ENSP00000387343 ENST00000409182	B9A070 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	195 aa 20.8 kDa	No	0
HES6-007 ENSP00000387107 ENST00000409356	B8ZZP9 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Show all		94 aa 10.3 kDa	No	0
HES6-008 ENSP00000390870 ENST00000450098	C9JF41 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Show all		145 aa 15.6 kDa	No	0
HES6-009 ENSP00000401797 ENST00000417803	H7C1R4 [Direct mapping] Transcription cofactor HES-6 Show all	Predicted intracellular proteins Show all		16 aa 2 kDa	No	0