Tissue expression of CTDSP1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CTDSP1
Gene description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CTDSP1 (HGNC Symbol)
Synonyms	NLIIF, SCP1
Description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218398256 - 218405941
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144579 (version 83.38)
Entrez gene	58190
UniProt	Q9GZU7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZU7
Antibodypedia	CTDSP1 antibodies

PROTEIN BROWSER

CTDSP1-001	CTDSP1-002	CTDSP1-008	CTDSP1-011	CTDSP1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTDSP1-001 ENSP00000273062 ENST00000273062	Q9GZU7 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 A0A024R461 [Target identity:100%; Query identity:100%] CTD (Carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006470 [protein dephosphorylation] GO:0008420 [CTD phosphatase activity] GO:0016791 [phosphatase activity] GO:0045665 [negative regulation of neuron differentiation] GO:0046872 [metal ion binding] GO:0050768 [negative regulation of neurogenesis] GO:0070062 [extracellular exosome] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	261 aa 29.2 kDa	No	0
CTDSP1-002 ENSP00000392248 ENST00000443891	Q9GZU7 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006470 [protein dephosphorylation] GO:0008420 [CTD phosphatase activity] GO:0016791 [phosphatase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	260 aa 29.1 kDa	No	0
CTDSP1-008 ENSP00000411308 ENST00000431127	H7C3E0 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		196 aa 21.1 kDa	No	0
CTDSP1-011 ENSP00000403256 ENST00000428361	H7C1Z7 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	262 aa 29.1 kDa	No	0
CTDSP1-012 ENSP00000404301 ENST00000452977	H7C270 [Direct mapping] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	254 aa 28.4 kDa	No	0