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Most malignancies showed weak cytoplasmic and/or nuclear positivity or were negative. Colorectal, ovarian and breast cancers were moderately stained in several cases.
GENE INFORMATION
Gene name
MARCH4 (HGNC Symbol)
Synonyms
KIAA1399, MARCH-IV, RNF174
Description
Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
