Cell atlas - CNTN4 - The Human Protein Atlas

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CNTN4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CNTN4
Gene description	Contactin 4
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (SH-SY5Y, BEWO, CACO-2, WM-115, HEK 293)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SH-SY5Y, BEWO, CACO-2, WM-115, HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CNTN4 (HGNC Symbol)
Synonyms	BIG-2
Description	Contactin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Chromosome	3
Cytoband
Chromosome location (bp)	2098813 - 3057956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144619 (version 83.38)
Entrez gene	152330
UniProt	Q8IWV2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWV2
Antibodypedia	CNTN4 antibodies

PROTEIN BROWSER

CNTN4-001	CNTN4-002	CNTN4-004	CNTN4-005	CNTN4-009	CNTN4-011	CNTN4-015	CNTN4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTN4-001 ENSP00000380602 ENST00000397461	Q8IWV2 [Direct mapping] Contactin-4 A0A024R2E5 [Target identity:100%; Query identity:100%] Contactin 4, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007420 [brain development] GO:0030424 [axon] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0045665 [negative regulation of neuron differentiation] GO:0048167 [regulation of synaptic plasticity] Show all	1026 aa 113.5 kDa	Yes	0
CNTN4-002 ENSP00000380600 ENST00000397459	Q8IWV2 [Direct mapping] Contactin-4 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007420 [brain development] GO:0030424 [axon] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0045665 [negative regulation of neuron differentiation] GO:0048167 [regulation of synaptic plasticity] Show all	698 aa 76.7 kDa	No	0
CNTN4-004 ENSP00000408594 ENST00000422330	C9JMQ2 [Direct mapping] Contactin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	116 aa 13 kDa	Yes	0
CNTN4-005 ENSP00000390560 ENST00000455083	C9JGK9 [Direct mapping] Contactin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 6.2 kDa	Yes	0
CNTN4-009 ENSP00000396010 ENST00000418658	Q8IWV2 [Direct mapping] Contactin-4 A0A024R2E5 [Target identity:100%; Query identity:100%] Contactin 4, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007420 [brain development] GO:0030424 [axon] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0045665 [negative regulation of neuron differentiation] GO:0048167 [regulation of synaptic plasticity] Show all	1026 aa 113.5 kDa	Yes	0
CNTN4-011 ENSP00000404085 ENST00000434053	C9JIY1 [Direct mapping] Contactin-4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	137 aa 15.2 kDa	Yes	0
CNTN4-015 ENSP00000422120 ENST00000473845	H0Y8U1 [Direct mapping] Contactin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	143 aa 15.9 kDa	No	0
CNTN4-201 ENSP00000413642 ENST00000427331	Q8IWV2 [Direct mapping] Contactin-4 A0A024R2E5 [Target identity:100%; Query identity:100%] Contactin 4, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007399 [nervous system development] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007420 [brain development] GO:0030424 [axon] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0045665 [negative regulation of neuron differentiation] GO:0048167 [regulation of synaptic plasticity] Show all	1026 aa 113.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.