Expression of ACKR2 in cancer - Summary

CANCER ATLAS

Gene description

Atypical chemokine receptor 2

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA013819

GENE INFORMATION
Gene name	ACKR2 (HGNC Symbol)
Synonyms	CCBP2, CCR10, CCR9, CMKBR9, D6
Description	Atypical chemokine receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.1
Chromosome location (bp)	42804752 - 42887974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144648 (version 83.38)
Entrez gene	1238
UniProt	O00590 (UniProt - Evidence at protein level)
neXtProt	NX_O00590
Antibodypedia	ACKR2 antibodies

PROTEIN BROWSER

ACKR2-001	ACKR2-003	ACKR2-007	ACKR2-011	ACKR2-012	ACKR2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACKR2-001 ENSP00000416996 ENST00000422265	O00590 [Direct mapping] Atypical chemokine receptor 2 A0A024R2X7 [Target identity:100%; Query identity:100%] Chemokine binding protein 2, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016493 [C-C chemokine receptor activity] GO:0016494 [C-X-C chemokine receptor activity] GO:0019957 [C-C chemokine binding] GO:0042119 [neutrophil activation] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] Show all	384 aa 43.4 kDa	No	7
ACKR2-003 ENSP00000396150 ENST00000442925	O00590 [Direct mapping] Atypical chemokine receptor 2 A0A024R2X7 [Target identity:100%; Query identity:100%] Chemokine binding protein 2, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005044 [scavenger receptor activity] GO:0005769 [early endosome] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0042119 [neutrophil activation] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] Show all	384 aa 43.4 kDa	No	7
ACKR2-007 ENSP00000476901 ENST00000497921	V9GYM0 [Direct mapping] Atypical chemokine receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	125 aa 14.3 kDa	No	2
ACKR2-011 ENSP00000477475 ENST00000492609	V9GZ70 [Direct mapping] Atypical chemokine receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	142 aa 16.3 kDa	No	3
ACKR2-012 ENSP00000477157 ENST00000494619	V9GYX0 [Direct mapping] Atypical chemokine receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0042119 [neutrophil activation] GO:0070098 [chemokine-mediated signaling pathway] Show all	170 aa 19.6 kDa	No	3
ACKR2-013 ENSP00000476581 ENST00000493193	V9GYB7 [Direct mapping] Atypical chemokine receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016494 [C-X-C chemokine receptor activity] GO:0042119 [neutrophil activation] GO:0070098 [chemokine-mediated signaling pathway] Show all	233 aa 26.8 kDa	No	5