Cell atlas - CSRNP1 - The Human Protein Atlas

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CSRNP1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	CSRNP1
Gene description	Cysteine-serine-rich nuclear protein 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles.
RNA cell category	Cell line enhanced (SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA045207 , HPA058463
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

Nucleoplasm (validated)

Additional location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045207	A-431	Nucleoplasm
	HPA045207	U-2 OS	Nucleoplasm
	HPA045207	U-251 MG	Nucleoplasm
	HPA058463	A-431	Nucleoplasm
	HPA058463	A-431	Vesicles
	HPA058463	U-2 OS	Nucleoplasm
	HPA058463	U-2 OS	Vesicles
	HPA058463	U-251 MG	Nucleoplasm
	HPA058463	U-251 MG	Vesicles

GENE INFORMATION
Gene name	CSRNP1 (HGNC Symbol)
Synonyms	AXUD1, DKFZp566F164, FAM130B, TAIP-3, URAX1
Description	Cysteine-serine-rich nuclear protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	39141855 - 39154562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144655 (version 83.38)
Entrez gene	64651
UniProt	Q96S65 (UniProt - Evidence at protein level)
neXtProt	NX_Q96S65
Antibodypedia	CSRNP1 antibodies

PROTEIN BROWSER

CSRNP1-001	CSRNP1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSRNP1-001 ENSP00000273153 ENST00000273153	Q96S65 [Direct mapping] Cysteine/serine-rich nuclear protein 1 A0A024R2N7 [Target identity:100%; Query identity:100%] AXIN1 up-regulated 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Show all	GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0009791 [post-embryonic development] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048705 [skeletal system morphogenesis] GO:0060021 [palate development] GO:0060325 [face morphogenesis] Show all	589 aa 63.5 kDa	No	0
CSRNP1-003 ENSP00000422532 ENST00000514182	Q96S65 [Direct mapping] Cysteine/serine-rich nuclear protein 1 A0A024R2N7 [Target identity:100%; Query identity:100%] AXIN1 up-regulated 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Show all	GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	589 aa 63.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.