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Malignant cells displayed moderate to strong granular cytoplasmic positivity. A few cases of renal cancers were weakly stained.
GENE INFORMATION
Gene name
GOLGA4 (HGNC Symbol)
Synonyms
GCP2, GOLG, golgin-240, p230
Description
Golgin A4 (HGNC Symbol)
Entrez gene summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]