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Most of the malignant tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in a few cases. A few cases of pancreatic cancers were strongly stained. Many malignant carcinoids, gliomas, lymphomas, melanomas, lung and renal cancers were negative.
Most malignant tissues exhibited weak to moderate cytoplasmic positivity. Rare colorectal, head and neck cancers showed strong positivity. Many cases of renal cancer was negative.
GENE INFORMATION
Gene name
RPL32 (HGNC Symbol)
Synonyms
L32
Description
Ribosomal protein L32 (HGNC Symbol)
Entrez gene summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]