Expression of ARL6IP5 in cancer - Summary

CANCER ATLAS

Gene description

ADP-ribosylation factor-like 6 interacting protein 5

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015540	CAB019321

GENE INFORMATION
Gene name	ARL6IP5 (HGNC Symbol)
Synonyms	DERP11, GTRAP3-18, HSPC127, JWA, PRAF3
Description	ADP-ribosylation factor-like 6 interacting protein 5 (HGNC Symbol)
Entrez gene summary	Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	69084944 - 69106066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144746 (version 83.38)
Entrez gene	10550
UniProt	O75915 (UniProt - Evidence at protein level)
neXtProt	NX_O75915
Antibodypedia	ARL6IP5 antibodies

PROTEIN BROWSER

ARL6IP5-001	ARL6IP5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARL6IP5-001 ENSP00000273258 ENST00000273258	O75915 [Direct mapping] PRA1 family protein 3 A0A024R371 [Target identity:100%; Query identity:100%] ADP-ribosylation-like factor 6 interacting protein 5, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0070062 [extracellular exosome] Show all	188 aa 21.6 kDa	No	3
ARL6IP5-002 ENSP00000420138 ENST00000478935	C9JQU6 [Direct mapping] PRA1 family protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	88 aa 10.3 kDa	No	1