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PHLDB2

CANCER ATLAS

Gene description

 Pleckstrin homology-like domain, family B, member 2

Protein class

 Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035147

GENE INFORMATION

Gene name

 PHLDB2 (HGNC Symbol)

Synonyms

 FLJ21791, LL5b, LL5beta

Description

 Pleckstrin homology-like domain, family B, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q13.2

Chromosome location (bp)

 111732497 - 111976517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144824 (version 83.38)

Entrez gene

 90102

UniProt

 Q86SQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86SQ0

Antibodypedia

 PHLDB2 antibodies

PROTEIN BROWSER
PHLDB2-001
PHLDB2-002
PHLDB2-003
PHLDB2-004
PHLDB2-005
PHLDB2-006
PHLDB2-008
PHLDB2-009
PHLDB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHLDB2-001
ENSP00000405405
ENST00000431670
Q86SQ0 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0031252 [cell leading edge]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045180 [basal cortex]
GO:0045184 [establishment of protein localization]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1253 aa
142.2 kDa 		No 0
PHLDB2-002
ENSP00000377500
ENST00000393923
Q86SQ0 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0031252 [cell leading edge]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045180 [basal cortex]
GO:0045184 [establishment of protein localization]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1237 aa
140 kDa 		No 0
PHLDB2-003
ENSP00000418319
ENST00000481953
Q86SQ0 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0031252 [cell leading edge]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045180 [basal cortex]
GO:0045184 [establishment of protein localization]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1210 aa
136.9 kDa 		No 0
PHLDB2-004
ENSP00000420303
ENST00000495180
E9PGF6 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 744 aa
86.6 kDa 		No 0
PHLDB2-005
ENSP00000417497
ENST00000478922
E9PDY7 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 519 aa
56.9 kDa 		No 2
PHLDB2-006
ENSP00000418198
ENST00000477695
G5E9V3 [Direct mapping]
Pleckstrin homology-like domain family B member 2; Pleckstrin homology-like domain, family B, member 2, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 581 aa
64.2 kDa 		No 0
PHLDB2-008
ENSP00000418296
ENST00000498699
E9PFQ4 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 1115 aa
125.5 kDa 		No 0
PHLDB2-009
ENSP00000377502
ENST00000393925
Q86SQ0 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0031252 [cell leading edge]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045180 [basal cortex]
GO:0045184 [establishment of protein localization]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1253 aa
142.2 kDa 		No 0
PHLDB2-201
ENSP00000405292
ENST00000412622
Q86SQ0 [Direct mapping]
Pleckstrin homology-like domain family B member 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010470 [regulation of gastrulation]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0031252 [cell leading edge]
GO:0045111 [intermediate filament cytoskeleton]
GO:0045180 [basal cortex]
GO:0045184 [establishment of protein localization]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1210 aa
136.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.