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ALDH1L1

CANCER ATLAS

Gene description

 Aldehyde dehydrogenase 1 family, member L1

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036900

GENE INFORMATION

Gene name

 ALDH1L1 (HGNC Symbol)

Synonyms

 10-fTHF, FTHFD

Description

 Aldehyde dehydrogenase 1 family, member L1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 126103562 - 126197994

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144908 (version 83.38)

Entrez gene

 10840

UniProt

 O75891 (UniProt - Evidence at protein level)

neXtProt

 NX_O75891

Antibodypedia

 ALDH1L1 antibodies

PROTEIN BROWSER
ALDH1L1-001
ALDH1L1-002
ALDH1L1-004
ALDH1L1-005
ALDH1L1-006
ALDH1L1-007
ALDH1L1-015
ALDH1L1-016
ALDH1L1-201
ALDH1L1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1L1-001
ENSP00000273450
ENST00000273450
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 912 aa
99.8 kDa 		No 0
ALDH1L1-002
ENSP00000377083
ENST00000393434
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 902 aa
98.8 kDa 		No 0
ALDH1L1-004
ENSP00000418711
ENST00000490367
C9IZ36 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
Show all
 177 aa
19.6 kDa 		No 0
ALDH1L1-005
ENSP00000419955
ENST00000488356
C9JY00 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
Show all
 157 aa
17.3 kDa 		No 0
ALDH1L1-006
ENSP00000419826
ENST00000460368
C9JYZ6 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
Show all
 168 aa
18.6 kDa 		No 0
ALDH1L1-007
ENSP00000420293
ENST00000472186
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 902 aa
98.8 kDa 		No 0
ALDH1L1-015
ENSP00000426594
ENST00000509952
D6RFJ7 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0009058 [biosynthetic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0055114 [oxidation-reduction process]
Show all
 100 aa
11 kDa 		No 0
ALDH1L1-016
ENSP00000395881
ENST00000452905
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 801 aa
87.6 kDa 		No 0
ALDH1L1-201
ENSP00000377081
ENST00000393431
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 505 aa
55.4 kDa 		No 0
ALDH1L1-202
ENSP00000414126
ENST00000455064
O75891 [Direct mapping]
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 505 aa
55.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.