Expression of TBCK in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

TBC1 domain containing kinase

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039951

GENE INFORMATION
Gene name	TBCK (HGNC Symbol)
Synonyms	HSPC302, MGC16169
Description	TBC1 domain containing kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	106041599 - 106321495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145348 (version 83.38)
Entrez gene	93627
UniProt	Q8TEA7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TEA7
Antibodypedia	TBCK antibodies

PROTEIN BROWSER

TBCK-001	TBCK-002	TBCK-003	TBCK-006	TBCK-008	TBCK-009	TBCK-013	TBCK-019	TBCK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBCK-001 ENSP00000273980 ENST00000273980	Q8TEA7 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	893 aa 100.7 kDa	No	0
TBCK-002 ENSP00000355338 ENST00000361687	Q8TEA7 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	830 aa 93.7 kDa	No	0
TBCK-003 ENSP00000378196 ENST00000394706	Q8TEA7 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Enzymes Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	854 aa 96.4 kDa	No	0
TBCK-006 ENSP00000378198 ENST00000394708	Q8TEA7 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	893 aa 100.7 kDa	No	0
TBCK-008 ENSP00000425197 ENST00000509862	D6RDY5 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	105 aa 11.8 kDa	No	0
TBCK-009 ENSP00000423637 ENST00000507696	D6R950 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.6 kDa	No	0
TBCK-013 ENSP00000423834 ENST00000503516	D6RC61 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.2 kDa	No	0
TBCK-019 ENSP00000420985 ENST00000509532	D6RDG2 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	159 aa 17.9 kDa	No	0
TBCK-201 ENSP00000405847 ENST00000432496	Q8TEA7 [Direct mapping] TBC domain-containing protein kinase-like protein Show all	Enzymes Kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	893 aa 100.7 kDa	No	0