Cell atlas - MARCH1 - The Human Protein Atlas

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MARCH1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	MARCH1
Gene description	Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA014600
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014600	A-431	Mitochondria
	HPA014600	U-2 OS	Mitochondria
	HPA014600	U-251 MG	No staining

GENE INFORMATION
Gene name	MARCH1 (HGNC Symbol)
Synonyms	FLJ20668, MARCH-I, RNF171
Description	Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Chromosome	4
Cytoband
Chromosome location (bp)	163524298 - 164384050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145416 (version 83.38)
Entrez gene	55016
UniProt	Q8TCQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCQ1
Antibodypedia	MARCH1 antibodies

PROTEIN BROWSER

MARCH1-002	MARCH1-003	MARCH1-004	MARCH1-007	MARCH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH1-002 ENSP00000427223 ENST00000503008	Q8TCQ1 [Direct mapping] E3 ubiquitin-protein ligase MARCH1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002495 [antigen processing and presentation of peptide antigen via MHC class II] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032588 [trans-Golgi network membrane] GO:0042287 [MHC protein binding] GO:0061630 [ubiquitin protein ligase activity] Show all	289 aa 32.3 kDa	No	2
MARCH1-003 ENSP00000421322 ENST00000514618	D6RGC4 [Direct mapping] E3 ubiquitin-protein ligase MARCH1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	545 aa 61.7 kDa	No	2
MARCH1-004 ENSP00000345676 ENST00000339875	Q8TCQ1 [Direct mapping] E3 ubiquitin-protein ligase MARCH1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002495 [antigen processing and presentation of peptide antigen via MHC class II] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032588 [trans-Golgi network membrane] GO:0042287 [MHC protein binding] Show all	272 aa 30.9 kDa	No	2
MARCH1-007 ENSP00000426731 ENST00000507270	D6REN1 [Direct mapping] E3 ubiquitin-protein ligase MARCH1 Show all	Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] Show all	141 aa 15.6 kDa	No	0
MARCH1-201 ENSP00000274056 ENST00000274056	Q8TCQ1 [Direct mapping] E3 ubiquitin-protein ligase MARCH1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000209 [protein polyubiquitination] GO:0002495 [antigen processing and presentation of peptide antigen via MHC class II] GO:0004842 [ubiquitin-protein transferase activity] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0032588 [trans-Golgi network membrane] GO:0042287 [MHC protein binding] Show all	289 aa 32.3 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.