Expression of NDUFS6 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA064221

GENE INFORMATION
Gene name	NDUFS6 (HGNC Symbol)
Synonyms	CI-13kA
Description	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	1801400 - 1816605
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145494 (version 83.38)
Entrez gene	4726
UniProt	O75380 (UniProt - Evidence at protein level)
neXtProt	NX_O75380
Antibodypedia	NDUFS6 antibodies

PROTEIN BROWSER

NDUFS6-001	NDUFS6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFS6-001 ENSP00000274137 ENST00000274137	O75380 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Q6IBC4 [Target identity:100%; Query identity:100%] NADH dehydrogenase (Ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase), isoform CRA_a; NDUFS6 protein; cDNA FLJ12441 fis, clone NT2RM1000132, highly similar to NADH-ubiquinone oxidoreductase 13 kDa-A subunit, mitochondrial (EC 1.6.5.3) Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006631 [fatty acid metabolic process] GO:0006936 [muscle contraction] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0010259 [multicellular organismal aging] GO:0022904 [respiratory electron transport chain] GO:0035264 [multicellular organism growth] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0061458 [reproductive system development] GO:0070584 [mitochondrion morphogenesis] GO:0072358 [cardiovascular system development] Show all	124 aa 13.7 kDa	No	0
NDUFS6-002 ENSP00000422557 ENST00000469176	D6RBT3 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.8 kDa	No	0