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SRD5A1

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GENERAL INFORMATION

Gene name

 SRD5A1

Gene description

 Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SRD5A1

Synonyms

Description

 Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (HGNC Symbol)

Entrez gene summary

 Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 6633343 - 6674386

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145545 (version 83.38)

Entrez gene

 6715

UniProt

 P18405 (UniProt - Evidence at protein level)

neXtProt

 NX_P18405

Antibodypedia

 SRD5A1 antibodies

PROTEIN BROWSER
SRD5A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRD5A1-001
ENSP00000274192
ENST00000274192
P18405 [Direct mapping]
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001655 [urogenital system development]
GO:0001889 [liver development]
GO:0003865 [3-oxo-5-alpha-steroid 4-dehydrogenase activity]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006629 [lipid metabolic process]
GO:0006694 [steroid biosynthetic process]
GO:0006702 [androgen biosynthetic process]
GO:0007530 [sex determination]
GO:0007548 [sex differentiation]
GO:0008202 [steroid metabolic process]
GO:0008209 [androgen metabolic process]
GO:0008584 [male gonad development]
GO:0009055 [electron carrier activity]
GO:0009267 [cellular response to starvation]
GO:0014070 [response to organic cyclic compound]
GO:0014850 [response to muscle activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016101 [diterpenoid metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0021510 [spinal cord development]
GO:0021766 [hippocampus development]
GO:0021794 [thalamus development]
GO:0021854 [hypothalamus development]
GO:0021983 [pituitary gland development]
GO:0021987 [cerebral cortex development]
GO:0030154 [cell differentiation]
GO:0030539 [male genitalia development]
GO:0030540 [female genitalia development]
GO:0032354 [response to follicle-stimulating hormone]
GO:0032355 [response to estradiol]
GO:0032869 [cellular response to insulin stimulus]
GO:0033218 [amide binding]
GO:0033574 [response to testosterone]
GO:0042428 [serotonin metabolic process]
GO:0042448 [progesterone metabolic process]
GO:0042493 [response to drug]
GO:0042747 [circadian sleep/wake cycle, REM sleep]
GO:0043025 [neuronal cell body]
GO:0043209 [myelin sheath]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0047751 [cholestenone 5-alpha-reductase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055114 [oxidation-reduction process]
GO:0060348 [bone development]
GO:0060416 [response to growth hormone]
GO:0060992 [response to fungicide]
GO:0070402 [NADPH binding]
GO:0070852 [cell body fiber]
GO:0071320 [cellular response to cAMP]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071394 [cellular response to testosterone stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071872 [cellular response to epinephrine stimulus]
Show all
 259 aa
29.5 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.