Expression of GZMA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Protein class

Enzymes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054134

GENE INFORMATION
Gene name	GZMA (HGNC Symbol)
Synonyms	CTLA3, HFSP
Description	Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (HGNC Symbol)
Entrez gene summary	Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	55102648 - 55110252
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145649 (version 83.38)
Entrez gene	3001
UniProt	P12544 (UniProt - Evidence at protein level)
neXtProt	NX_P12544
Antibodypedia	GZMA antibodies

PROTEIN BROWSER

GZMA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GZMA-001 ENSP00000274306 ENST00000274306	P12544 [Direct mapping] Granzyme A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001772 [immunological synapse] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0019835 [cytolysis] GO:0032078 [negative regulation of endodeoxyribonuclease activity] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0051354 [negative regulation of oxidoreductase activity] GO:0051603 [proteolysis involved in cellular protein catabolic process] Show all	262 aa 29 kDa	Yes	0