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PIK3R1

CANCER ATLAS

Gene description

 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Protein class

 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001216
CAB004268

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

 PIK3R1 (HGNC Symbol)

Synonyms

 GRB1, p85, p85-ALPHA

Description

 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Chromosome

 5

Cytoband

 q13.1

Chromosome location (bp)

 68215720 - 68301821

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145675 (version 83.38)

Entrez gene

 5295

UniProt

 P27986 (UniProt - Evidence at protein level)

neXtProt

 NX_P27986

Antibodypedia

 PIK3R1 antibodies

PROTEIN BROWSER
PIK3R1-001
PIK3R1-002
PIK3R1-003
PIK3R1-004
PIK3R1-009
PIK3R1-010
PIK3R1-011
PIK3R1-014
PIK3R1-015
PIK3R1-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3R1-001
ENSP00000428056
ENST00000521381
P27986 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005801 [cis-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019903 [protein phosphatase binding]
GO:0030168 [platelet activation]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0031295 [T cell costimulation]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033120 [positive regulation of RNA splicing]
GO:0034644 [cellular response to UV]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035014 [phosphatidylinositol 3-kinase regulator activity]
GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045671 [negative regulation of osteoclast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0046982 [protein heterodimerization activity]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051492 [regulation of stress fiber assembly]
GO:0051531 [NFAT protein import into nucleus]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0090003 [regulation of establishment of protein localization to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1990578 [perinuclear endoplasmic reticulum membrane]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 724 aa
83.6 kDa 		No 0
PIK3R1-002
ENSP00000323512
ENST00000320694
P27986 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019903 [protein phosphatase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0032869 [cellular response to insulin stimulus]
GO:0033120 [positive regulation of RNA splicing]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035014 [phosphatidylinositol 3-kinase regulator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 424 aa
50 kDa 		No 0
PIK3R1-003
ENSP00000338554
ENST00000336483
P27986 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019903 [protein phosphatase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0032869 [cellular response to insulin stimulus]
GO:0033120 [positive regulation of RNA splicing]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035014 [phosphatidylinositol 3-kinase regulator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 454 aa
53.5 kDa 		No 0
PIK3R1-004
ENSP00000430098
ENST00000523872
P27986 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019903 [protein phosphatase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0032869 [cellular response to insulin stimulus]
GO:0033120 [positive regulation of RNA splicing]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035014 [phosphatidylinositol 3-kinase regulator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 361 aa
42.8 kDa 		No 0
PIK3R1-009
ENSP00000430126
ENST00000523807
E5RGI8 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 117 aa
13.3 kDa 		No 0
PIK3R1-010
ENSP00000429766
ENST00000522084
E5RHI0 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 102 aa
11.5 kDa 		No 0
PIK3R1-011
ENSP00000431058
ENST00000521409
E5RJY0 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 137 aa
16.3 kDa 		No 0
PIK3R1-014
ENSP00000428566
ENST00000520675
H0YB27 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 132 aa
14.8 kDa 		No 0
PIK3R1-015
ENSP00000429156
ENST00000519025
H0YBC2 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0008286 [insulin receptor signaling pathway]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 189 aa
22.4 kDa 		No 0
PIK3R1-016
ENSP00000429277
ENST00000521657
P27986 [Direct mapping]
Phosphatidylinositol 3-kinase regulatory subunit alpha
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019903 [protein phosphatase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0032869 [cellular response to insulin stimulus]
GO:0033120 [positive regulation of RNA splicing]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035014 [phosphatidylinositol 3-kinase regulator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043125 [ErbB-3 class receptor binding]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0043559 [insulin binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046326 [positive regulation of glucose import]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050821 [protein stabilization]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 724 aa
83.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.