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IQGAP2

GENERAL INFORMATION

Gene name

 IQGAP2

Gene description

 IQ motif containing GTPase activating protein 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA037403 , HPA037404 , CAB004241
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IQGAP2

Synonyms

Description

 IQ motif containing GTPase activating protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 76403249 - 76708132

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145703 (version 83.38)

Entrez gene

 10788

UniProt

 Q13576 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13576

Antibodypedia

 IQGAP2 antibodies

PROTEIN BROWSER
IQGAP2-001
IQGAP2-002
IQGAP2-003
IQGAP2-004
IQGAP2-005
IQGAP2-006
IQGAP2-012
IQGAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IQGAP2-001
ENSP00000274364
ENST00000274364
Q13576 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005095 [GTPase inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005902 [microvillus]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009986 [cell surface]
GO:0015629 [actin cytoskeleton]
GO:0017048 [Rho GTPase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0031941 [filamentous actin]
GO:0034260 [negative regulation of GTPase activity]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048365 [Rac GTPase binding]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070493 [thrombin receptor signaling pathway]
GO:0071933 [Arp2/3 complex binding]
Show all
 1575 aa
180.6 kDa 		No 0
IQGAP2-002
ENSP00000423672
ENST00000514350
D6R939 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 825 aa
94.8 kDa 		No 0
IQGAP2-003
ENSP00000421097
ENST00000505766
E7EWC2 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1402 aa
160.3 kDa 		No 0
IQGAP2-004
ENSP00000422661
ENST00000514001
E9PDT6 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 509 aa
59.2 kDa 		No 0
IQGAP2-005
ENSP00000379535
ENST00000396234
Q13576 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005095 [GTPase inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009986 [cell surface]
GO:0015629 [actin cytoskeleton]
GO:0017048 [Rho GTPase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0031941 [filamentous actin]
GO:0034260 [negative regulation of GTPase activity]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048365 [Rac GTPase binding]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070493 [thrombin receptor signaling pathway]
GO:0071933 [Arp2/3 complex binding]
Show all
 1071 aa
122.8 kDa 		No 0
IQGAP2-006
ENSP00000426027
ENST00000502745
Q13576 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005095 [GTPase inhibitor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009986 [cell surface]
GO:0015629 [actin cytoskeleton]
GO:0017048 [Rho GTPase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0031941 [filamentous actin]
GO:0034260 [negative regulation of GTPase activity]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048365 [Rac GTPase binding]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
GO:0070493 [thrombin receptor signaling pathway]
GO:0071933 [Arp2/3 complex binding]
Show all
 1071 aa
122.8 kDa 		No 0
IQGAP2-012
ENSP00000425351
ENST00000509074
D6RDK8 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 167 aa
18.3 kDa 		No 0
IQGAP2-201
ENSP00000442313
ENST00000379730
F5H7S7 [Direct mapping]
Ras GTPase-activating-like protein IQGAP2
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1525 aa
174.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.