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Cytoplasmic expression in neuroendocrine cells, islets of Langerhans and heart muscle.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity] GO:0004504 [peptidylglycine monooxygenase activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0006518 [peptide metabolic process] GO:0016020 [membrane] GO:0016715 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen] GO:0055114 [oxidation-reduction process]