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SLC30A5

GENERAL INFORMATION

Gene name

 SLC30A5

Gene description

 Solute carrier family 30 (zinc transporter), member 5

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035373
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC30A5 (HGNC Symbol)

Synonyms

 FLJ12496, FLJ12756, MGC5499, ZnT-5, ZNT5, ZNTL1, ZTL1

Description

 Solute carrier family 30 (zinc transporter), member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

Chromosome

 5

Cytoband

Chromosome location (bp)

 69093646 - 69131069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145740 (version 83.38)

Entrez gene

 64924

UniProt

 Q8TAD4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAD4

Antibodypedia

 SLC30A5 antibodies

PROTEIN BROWSER
SLC30A5-001
SLC30A5-002
SLC30A5-003
SLC30A5-005
SLC30A5-008
SLC30A5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC30A5-001
ENSP00000379836
ENST00000396591
Q8TAD4 [Direct mapping]
Zinc transporter 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0006824 [cobalt ion transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0008324 [cation transmembrane transporter activity]
GO:0010043 [response to zinc ion]
GO:0010155 [regulation of proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 765 aa
84 kDa 		No >9
SLC30A5-002
ENSP00000370241
ENST00000380860
Q8TAD4 [Direct mapping]
Zinc transporter 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral component of plasma membrane]
GO:0006824 [cobalt ion transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0010043 [response to zinc ion]
GO:0010155 [regulation of proton transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 118 aa
12.9 kDa 		No 2
SLC30A5-003
ENSP00000421251
ENST00000502979
Q8TAD4 [Direct mapping]
Zinc transporter 5
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005887 [integral component of plasma membrane]
GO:0006824 [cobalt ion transport]
GO:0006829 [zinc II ion transport]
GO:0006882 [cellular zinc ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0010043 [response to zinc ion]
GO:0010155 [regulation of proton transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
Show all
 77 aa
8.2 kDa 		No 0
SLC30A5-005
ENSP00000426751
ENST00000504103
D6REM2 [Direct mapping]
Zinc transporter 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 72 aa
7.7 kDa 		No 1
SLC30A5-008
ENSP00000423078
ENST00000511158
H0Y957 [Direct mapping]
Zinc transporter 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 84 aa
9.4 kDa 		No 0
SLC30A5-201
ENSP00000483105
ENST00000621204
Q9BY48 [Direct mapping]
Putative disease resistance protein; Zinc transporter 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0098655 [cation transmembrane transport]
Show all
 360 aa
40.2 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.