Expression of DDX46 in cancer - Summary

CANCER ATLAS

Gene description

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036554

GENE INFORMATION
Gene name	DDX46 (HGNC Symbol)
Synonyms	FLJ25329, KIAA0801, Prp5, PRPF5
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	134758771 - 134855133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145833 (version 83.38)
Entrez gene	9879
UniProt	Q7L014 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L014
Antibodypedia	DDX46 antibodies

PROTEIN BROWSER

DDX46-001	DDX46-002	DDX46-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX46-001 ENSP00000416534 ENST00000452510	A0A0C4DG89 [Direct mapping] Probable ATP-dependent RNA helicase DDX46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0010501 [RNA secondary structure unwinding] Show all	1032 aa 117.5 kDa	No	0
DDX46-002 ENSP00000346236 ENST00000354283	Q7L014 [Direct mapping] Probable ATP-dependent RNA helicase DDX46 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010468 [regulation of gene expression] GO:0010501 [RNA secondary structure unwinding] GO:0015030 [Cajal body] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] Show all	1031 aa 117.4 kDa	No	0
DDX46-201 ENSP00000487025 ENST00000628477	D6RJA6 [Direct mapping] DEAD (Asp-Glu-Ala-Asp) box polypeptide 46, isoform CRA_b; Probable ATP-dependent RNA helicase DDX46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010468 [regulation of gene expression] GO:0010501 [RNA secondary structure unwinding] Show all	471 aa 54 kDa	No	0