Expression of GABRA6 in cancer - Summary

CANCER ATLAS

Gene description

Gamma-aminobutyric acid (GABA) A receptor, alpha 6

Protein class

FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019188	HPA058329	CAB022462

GENE INFORMATION
Gene name	GABRA6
Synonyms
Description	Gamma-aminobutyric acid (GABA) A receptor, alpha 6 (HGNC Symbol)
Entrez gene summary	GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q34
Chromosome location (bp)	161547063 - 161702593
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000145863 (version 83.38)
Entrez gene	2559
UniProt	Q16445 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16445
Antibodypedia	GABRA6 antibodies

PROTEIN BROWSER

GABRA6-001	GABRA6-003	GABRA6-007	GABRA6-008	GABRA6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABRA6-001 ENSP00000274545 ENST00000274545	Q16445 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005237 [inhibitory extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0008503 [benzodiazepine receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0042493 [response to drug] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	453 aa 51 kDa	Yes	4
GABRA6-003 ENSP00000430527 ENST00000523217	E7EV53 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0045202 [synapse] Show all	443 aa 49.7 kDa	Yes	4
GABRA6-007 ENSP00000429943 ENST00000520000	H0YBP3 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	197 aa 22.6 kDa	No	0
GABRA6-008 ENSP00000430212 ENST00000517823	H0YBS7 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-6 Show all	Predicted intracellular proteins Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	185 aa 21.2 kDa	No	0
GABRA6-009 ENSP00000427989 ENST00000523691	H0YAS3 [Direct mapping] Gamma-aminobutyric acid receptor subunit alpha-6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	191 aa 22 kDa	No	1