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GABRB2

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GENERAL INFORMATION

Gene name

 GABRB2

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, beta 2

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GABRB2

Synonyms

Description

 Gamma-aminobutyric acid (GABA) A receptor, beta 2 (HGNC Symbol)

Entrez gene summary

 The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q34

Chromosome location (bp)

 161288429 - 161549044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145864 (version 83.38)

Entrez gene

 2561

UniProt

 P47870 (UniProt - Evidence at protein level)

neXtProt

 NX_P47870

Antibodypedia

 GABRB2 antibodies

PROTEIN BROWSER
GABRB2-001
GABRB2-002
GABRB2-003
GABRB2-004
GABRB2-006
GABRB2-201
GABRB2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRB2-001
ENSP00000274546
ENST00000353437
P47870 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0051932 [synaptic transmission, GABAergic]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 474 aa
54.6 kDa 		Yes 4
GABRB2-002
ENSP00000377531
ENST00000393959
P47870 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0051932 [synaptic transmission, GABAergic]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 512 aa
59.1 kDa 		Yes 4
GABRB2-003
ENSP00000430532
ENST00000517901
E7EV50 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0045202 [synapse]
Show all
 411 aa
47.6 kDa 		No 4
GABRB2-004
ENSP00000429320
ENST00000520240
P47870 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0051932 [synaptic transmission, GABAergic]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 474 aa
54.6 kDa 		Yes 4
GABRB2-006
ENSP00000429750
ENST00000517547
B7Z279 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2; cDNA FLJ53759, highly similar to Gamma-aminobutyric-acid receptor subunit beta-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 314 aa
36.3 kDa 		No 4
GABRB2-201
ENSP00000274547
ENST00000274547
P47870 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005237 [inhibitory extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007605 [sensory perception of sound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016917 [GABA receptor activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048666 [neuron development]
GO:0050877 [neurological system process]
GO:0051932 [synaptic transmission, GABAergic]
GO:0055085 [transmembrane transport]
GO:0060119 [inner ear receptor cell development]
GO:0060384 [innervation]
GO:0070062 [extracellular exosome]
GO:0071420 [cellular response to histamine]
GO:0090102 [cochlea development]
GO:1901215 [negative regulation of neuron death]
GO:1902476 [chloride transmembrane transport]
GO:1902710 [GABA receptor complex]
GO:1902711 [GABA-A receptor complex]
Show all
 512 aa
59.1 kDa 		Yes 4
GABRB2-202
ENSP00000480066
ENST00000612710
P47870 [Direct mapping]
Gamma-aminobutyric acid receptor subunit beta-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0051932 [synaptic transmission, GABAergic]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071420 [cellular response to histamine]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 313 aa
36.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.