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G3BP1

GENERAL INFORMATION

Gene name

 G3BP1

Gene description

 GTPase activating protein (SH3 domain) binding protein 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004052 , CAB037068
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 G3BP1 (HGNC Symbol)

Synonyms

 G3BP, HDH-VIII

Description

 GTPase activating protein (SH3 domain) binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q33.1

Chromosome location (bp)

 151771045 - 151812785

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145907 (version 83.38)

Entrez gene

 10146

UniProt

 Q13283 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13283

Antibodypedia

 G3BP1 antibodies

PROTEIN BROWSER
G3BP1-001
G3BP1-002
G3BP1-007
G3BP1-008
G3BP1-009
G3BP1-012
G3BP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
G3BP1-001
ENSP00000377681
ENST00000394123
Q13283 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
Q5U0Q1 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein DKFZp686L1159; Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003729 [mRNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0007265 [Ras protein signal transduction]
GO:0010494 [cytoplasmic stress granule]
GO:0032508 [DNA duplex unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 466 aa
52.2 kDa 		No 0
G3BP1-002
ENSP00000348578
ENST00000356245
Q13283 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
Q5U0Q1 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein DKFZp686L1159; Ras-GTPase-activating protein SH3-domain-binding protein; Ras-GTPase-activating protein SH3-domain-binding protein, isoform CRA_a; cDNA, FLJ92947, Homo sapiens Ras-GTPase-activating protein SH3-domain-bindingprotein (G3BP), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0007265 [Ras protein signal transduction]
GO:0032508 [DNA duplex unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
 466 aa
52.2 kDa 		No 0
G3BP1-007
ENSP00000430738
ENST00000523519
E5RIF8 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0006810 [transport]
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 106 aa
12 kDa 		No 0
G3BP1-008
ENSP00000429920
ENST00000520578
E5RH42 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
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 117 aa
13.3 kDa 		No 0
G3BP1-009
ENSP00000429250
ENST00000507878
E5RIZ6 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
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 148 aa
17 kDa 		No 0
G3BP1-012
ENSP00000428469
ENST00000520006
E5RI46 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006810 [transport]
Show all
 105 aa
11.8 kDa 		No 0
G3BP1-201
ENSP00000486887
ENST00000627077
E5RH00 [Direct mapping]
Ras GTPase-activating protein-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 37 aa
4.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.