Expression of NHP2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

NHP2 ribonucleoprotein

Protein class

Disease related genes, Predicted intracellular proteins, Ribosomal proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044171	HPA050400

GENE INFORMATION
Gene name	NHP2 (HGNC Symbol)
Synonyms	FLJ20479, NOLA2
Description	NHP2 ribonucleoprotein (HGNC Symbol)
Entrez gene summary	This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	178149460 - 178153967
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145912 (version 83.38)
Entrez gene	55651
UniProt	Q9NX24 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NX24
Antibodypedia	NHP2 antibodies

PROTEIN BROWSER

NHP2-001	NHP2-002	NHP2-003	NHP2-004	NHP2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NHP2-001 ENSP00000274606 ENST00000274606	Q9NX24 [Direct mapping] H/ACA ribonucleoprotein complex subunit 2 Show all	Ribosomal proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005697 [telomerase holoenzyme complex] GO:0005732 [small nucleolar ribonucleoprotein complex] GO:0005737 [cytoplasm] GO:0007004 [telomere maintenance via telomerase] GO:0030515 [snoRNA binding] GO:0031118 [rRNA pseudouridine synthesis] GO:0031429 [box H/ACA snoRNP complex] GO:0044822 [poly(A) RNA binding] GO:0070034 [telomeric RNA binding] GO:0072589 [box H/ACA scaRNP complex] Show all	153 aa 17.2 kDa	No	0
NHP2-002 ENSP00000366276 ENST00000314397	J3QSY4 [Direct mapping] H/ACA ribonucleoprotein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	90 aa 10.1 kDa	No	0
NHP2-003 ENSP00000423803 ENST00000514354	D6RCB9 [Direct mapping] H/ACA ribonucleoprotein complex subunit 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	135 aa 15.2 kDa	No	0
NHP2-004 ENSP00000431126 ENST00000502263	H0YC83 [Direct mapping] H/ACA ribonucleoprotein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.6 kDa	No	0
NHP2-005 ENSP00000423849 ENST00000511078	D6RC52 [Direct mapping] H/ACA ribonucleoprotein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	132 aa 15 kDa	No	0