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CDKAL1

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GENERAL INFORMATION

Gene name

 CDKAL1

Gene description

 CDK5 regulatory subunit associated protein 1-like 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enriched (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA057474
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057474 HEK 293 Vesicles

GENE INFORMATION

Gene name

 CDKAL1 (HGNC Symbol)

Synonyms

 FLJ20342

Description

 CDK5 regulatory subunit associated protein 1-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 20534457 - 21232404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145996 (version 83.38)

Entrez gene

 54901

UniProt

 Q5VV42 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5VV42

Antibodypedia

 CDKAL1 antibodies

PROTEIN BROWSER
CDKAL1-001
CDKAL1-201
CDKAL1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKAL1-001
ENSP00000367873
ENST00000378610
Q5VV42 [Direct mapping]
Threonylcarbamoyladenosine tRNA methylthiotransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0008150 [biological_process]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
GO:0035598 [N6-threonylcarbomyladenosine methylthiotransferase activity]
GO:0035600 [tRNA methylthiolation]
GO:0043412 [macromolecule modification]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061712 [tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase]
Show all
 579 aa
65.1 kDa 		No 1
CDKAL1-201
ENSP00000274695
ENST00000274695
Q5VV42 [Direct mapping]
Threonylcarbamoyladenosine tRNA methylthiotransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005791 [rough endoplasmic reticulum]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0008150 [biological_process]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016740 [transferase activity]
GO:0035598 [N6-threonylcarbomyladenosine methylthiotransferase activity]
GO:0035600 [tRNA methylthiolation]
GO:0043412 [macromolecule modification]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061712 [tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase]
GO:1990145 [maintenance of translational fidelity]
Show all
 579 aa
65.1 kDa 		No 1
CDKAL1-202
ENSP00000481755
ENST00000613575
Q5VV42 [Direct mapping]
Threonylcarbamoyladenosine tRNA methylthiotransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0008150 [biological_process]
GO:0009451 [RNA modification]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035598 [N6-threonylcarbomyladenosine methylthiotransferase activity]
GO:0035600 [tRNA methylthiolation]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0061712 [tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase]
Show all
 97 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.