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Several cases of liver cancers displayed moderate to strong membranous positivity. A subset of tumor cells in few cases of melanoma, endometrial, skin, testis, urothelial and lung cancers showed moderate to strong cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
SLC17A4 (HGNC Symbol)
Synonyms
KIAA2138
Description
Solute carrier family 17, member 4 (HGNC Symbol)
Entrez gene summary
Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]
