Cell atlas - PLA2G7 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PLA2G7

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PLA2G7
Gene description	Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein class	Candidate cardiovascular disease genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (PC-3, NTERA-2, U-2 OS, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA035916
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (PC-3, NTERA-2, U-2 OS, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035916	A-431	Vesicles
	HPA035916	U-2 OS	Vesicles
	HPA035916	U-251 MG	No staining

GENE INFORMATION
Gene name	PLA2G7 (HGNC Symbol)
Synonyms	LDL-PLA2, PAFAH
Description	Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	46704201 - 46735693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146070 (version 83.38)
Entrez gene	7941
UniProt	Q13093 (UniProt - Evidence at protein level)
neXtProt	NX_Q13093
Antibodypedia	PLA2G7 antibodies

PROTEIN BROWSER

PLA2G7-001	PLA2G7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G7-001 ENSP00000274793 ENST00000274793	Q13093 [Direct mapping] Platelet-activating factor acetylhydrolase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0016042 [lipid catabolic process] GO:0034362 [low-density lipoprotein particle] GO:0034374 [low-density lipoprotein particle remodeling] GO:0034440 [lipid oxidation] GO:0034441 [plasma lipoprotein particle oxidation] GO:0044267 [cellular protein metabolic process] GO:0047499 [calcium-independent phospholipase A2 activity] GO:0050729 [positive regulation of inflammatory response] GO:0090026 [positive regulation of monocyte chemotaxis] Show all	441 aa 50.1 kDa	Yes	0
PLA2G7-201 ENSP00000445666 ENST00000537365	Q13093 [Direct mapping] Platelet-activating factor acetylhydrolase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0016042 [lipid catabolic process] GO:0034362 [low-density lipoprotein particle] GO:0034374 [low-density lipoprotein particle remodeling] GO:0034440 [lipid oxidation] GO:0034441 [plasma lipoprotein particle oxidation] GO:0044267 [cellular protein metabolic process] GO:0047499 [calcium-independent phospholipase A2 activity] GO:0050729 [positive regulation of inflammatory response] GO:0090026 [positive regulation of monocyte chemotaxis] Show all	441 aa 50.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.