Cell atlas - PPP1R18 - The Human Protein Atlas

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PPP1R18

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PPP1R18
Gene description	Protein phosphatase 1, regulatory subunit 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA044745 , HPA051000
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleoplasm.

Main location

Plasma membrane (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA044745	A-431	Plasma membrane
HPA044745	U-2 OS	Plasma membrane
HPA044745	U-251 MG	Plasma membrane
HPA051000	A-431	Nucleoplasm
HPA051000	A-431	Plasma membrane
HPA051000	U-2 OS	Nucleoplasm
HPA051000	U-2 OS	Plasma membrane
HPA051000	U-251 MG	Nucleoplasm
HPA051000	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	PPP1R18 (HGNC Symbol)
Synonyms	KIAA1949, phostensin
Description	Protein phosphatase 1, regulatory subunit 18 (HGNC Symbol)
Entrez gene summary	Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	30676389 - 30687895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146112 (version 83.38)
Entrez gene	170954
UniProt	Q6NYC8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NYC8
Antibodypedia	PPP1R18 antibodies

PROTEIN BROWSER

PPP1R18-001	PPP1R18-002	PPP1R18-005	PPP1R18-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R18-001 ENSP00000274853 ENST00000274853	Q6NYC8 [Direct mapping] Phostensin A0A024RCJ8 [Target identity:100%; Query identity:100%] HCG1821276, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0019902 [phosphatase binding] Show all	613 aa 67.9 kDa	No	0
PPP1R18-002 ENSP00000382150 ENST00000399199	Q6NYC8 [Direct mapping] Phostensin A0A024RCJ8 [Target identity:100%; Query identity:100%] HCG1821276, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0019902 [phosphatase binding] Show all	613 aa 67.9 kDa	No	0
PPP1R18-005 ENSP00000482578 ENST00000615892	Q6NYC8 [Direct mapping] Phostensin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0019902 [phosphatase binding] Show all	165 aa 17.8 kDa	No	0
PPP1R18-201 ENSP00000480270 ENST00000615527	Q6NYC8 [Direct mapping] Phostensin A0A024RCJ8 [Target identity:100%; Query identity:100%] HCG1821276, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0019902 [phosphatase binding] Show all	613 aa 67.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.